This dataset provides potential suitable area for cultivating proso millet in the Karnali Province, Nepal. It is one of the datasets produced through a land suitability analysis conducted for high value agricultural commodities in the province. The suitability analysis was based on the FAO's' land suitability framework, which evaluates the suitability of land for cultivation of specific crop using climatic, topographic and soil characteristics. The analysis was conducted by ICIMOD under the Himalayan Resilience Enabling Action Programme (HI-REAP) project to support data-driven decision making and promote sustainable and climate-resilient agriculture in Karnali Province.